Day 1, Friday, November 16, 2018
| Good morning – Welcome Coffee, served prior to the start of the day | ||
| 8:30 a.m. – 9:15 a.m. | Opening Session | |
| 8:30 a.m. – 8:45 a.m. | Welcome and announcement of the “Young Investigator Award” Norbert Gleicher, MD and David F. Albertini, PhD |
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| 8:45 a.m. – 9:15 a.m. | The “Breaking News” lecture Understanding translational dysfunction in fragile X-associated neural and reproductive disorders.* Ethan J. Greenblatt, PhD *this talk is based on Greenblatt & Spradling, Science 2018; 361;709-712 |
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| 9:15 a.m. – 11:15 a.m. | Session 1 – Plenary: Where our journey is leading to – Part I Chairs: David F. Albertini, PhD and Norbert Gleicher, MD |
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| 9:15 a.m. – 9:45 a.m. | Beyond tech support: What physics brings to biology Eric D. Siggia, PhD |
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| 9:45 a.m. – 10:15 a.m. | Maneuvering between ethical concerns and the desire to advance science Eli Y. Adashi, MD, MS, MA |
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| 10:15 a.m. – 10:45 a.m. | Increased mTOR activity in FMR1 knockout mice and premature recruitment of oocyte pool reversed with rapamycin S. Zev Williams, MD, PhD |
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| 10:45 a.m. – 11:15 a.m. | How the FMR1 gene and the AKT/mTOR signaling pathways potentially control folliculogenesis Julia Rehnitz, MD |
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| 11:15 a.m. – 11:45 a.m. | Coffee Break, Poster Viewing & Visit the Exhibition | |
| 11:45 a.m. – 12:45 p.m. | Session 2 – Plenary: Where our journey is leading to – Part II Chairs: Neeta Singh, MD and Zeev Shoham, MD |
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| 11:45 a.m. – 12:15 p.m. | A first step in growing human primordial follicles in vitro to maturity in a multi-step culture system Evelyn E. Telfer, PhD |
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| 12:15 p.m. – 12:45 p.m. | Combining imaging and transcriptomics at single cell resolution to understand blastocyst formation Anna-Katerina Hadjantonakis, PhD |
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| 12:45 p.m. – 1:00 p.m. | Get your lunch “to-go” | |
| 1:00 p.m. –2:00 p.m. | Lunch break debate – bring your lunch
Chair: Norbert Gleicher, MD How effective is egg freezing as a preventative treatment for young women in securing their ability to reproduce later in life? – Very effective: Nicole Noyes, MD |
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| 2:00 p.m. – 3:30 p.m. | Session 3 – Paradigm change I: Clarifying the significance of chromosomal abnormalities in human embryos Chairs: Evelyn E. Telfer, PhD and Vitaly A. Kushnir, MD |
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| 2:00 p.m. – 2:30 p.m. | When chromosomal abnormalities are the norm Rajiv C. McCoy, PhD |
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| 2:30 p.m. – 3:00 p.m. | Explaining the purpose of PGS/PGT-A Nathan R. Treff, PhD |
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| 3:00 p.m. – 3:30 p.m. | Explaining the shortcomings of PGS/PGT-A Raoul Orvieto, MD |
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| 3:30 p.m. – 4:00 p.m. | Coffee Break, Poster Viewing & Visit the Exhibition | |
| 4:00 p.m. – 6:00 p.m. | Session 4 – Paradigm change II: Changing the thinking about PCOS Chairs: Nicole Noyes, MD and Raoul Orvieto, MD |
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| 4:00 p.m. – 4:30 p.m. | Why new diagnostic criteria for different PCOS phenotypes are urgently needed Ricardo Azziz, MD, MPH, MBA |
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| 4:30 p.m. – 5:00 p.m. | Using AMH to diagnose PCOS? Neeta Singh, MD |
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| 5:00 p.m. – 5:30 p.m. | A surprisingly common new hypo-androgenic PCOS-like phenotype Norbert Gleicher, MD |
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| 5:30 p.m. – 6:00 p.m. | Evidence for existence of a pituitary-adrenal-ovarian axis that controls ovarian function Vitaly A. Kushnir, MD |
Day 2, Saturday, November 17, 2018
| Good morning – Welcome Coffee, served prior to the start of the day | ||
| 8:30 a.m. – 10:30 a.m. | Session 5 – Plenary: Where our journey is leading to – Part III Chairs: Eli Y. Adashi, MD, MS, MA and Ricardo Azziz, MD, MPH, MBA |
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| 8:30 a.m. – 9:00 a.m. | “Sensing of the whole”: Morphodynamics of early embryo development Ilya Volodayev, PhD |
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| 9:00 a.m. – 9:30 a.m. | Genomic evidence for the importance of inflammation on IVF outcomes Marc-André Sirard, DMV, PhD |
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| 9:30 a.m. – 10:00 a.m. | E2F1-mediated epigenetic mechanism in ovarian response controls FMR1 expression in human granulosa cells Julia Rehnitz, PhD |
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| 10:00 a.m. – 10:30 a.m. | What autologous stem cell transplants are effective in the treatment of refractory Asherman’s syndrome? Neeta Singh, MD |
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| 10:30 a.m. – 11:00 a.m. | Coffee Break, Poster Viewing & Visit the Exhibition | |
| 11:00 a.m. – 12:00 p.m. | Session 6 – Plenary: Where our journey is leading to – Part IV Chairs: Marc-André Sirard, DMV, PhD and Julia Rehnitz, PhD |
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| 11:00 a.m. – 11:30 a.m. | Targeting mTOR signaling to preserve reproductive longevity Kara N. Goldman, MD |
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| 11:30 a.m. – 12:00 p.m. | Correlating micropattern differentiation of mouse pluripotent stem cells with mouse embryos, to inform human embryo cell fate patterning Anna-Katerina Hadjantonakis, PhD |
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| 12:00 p.m. – 12:15 p.m. | Get your lunch “to-go” | |
| 12:15 p.m. – 1:15 p.m. | Lunch break debate – bring your lunch
Chair: David H. Barad, MD, MS When is the right time to refer a patient into egg donation? – Above the age 42 and/or FSH 15.0-20.0 mIU/mL: Eli Y. Adashi, MD, MS, MA |
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| 1:15 p.m. – 3:00 p.m. | Session 7 – Paradigm change III: Individualizing IVF practice for best outcome by age and functional ovarian reserve Chairs: Kara N. Goldman, MD and Pasquale Patrizio, MD, MS |
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| 1:15 p.m. – 1:35 p.m. | Why follicles need adequate androgen levels Andrea Weghofer, MD, PhD, MS, MBA |
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| 1:35 p.m. – 1:55 p.m. | How to supplement hypo-androgenic women correctly Norbert Gleicher, MD |
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| 1:55 p.m. – 2:15 p.m. | The intra-follicular molecular biology mandating advancement of egg retrieval in some women David H. Barad, MD, MS |
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| 2:15 p.m. – 2:35 p.m. | HIER – Highly individualized egg retrieval Vitaly A. Kushnir, MD |
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| 2:35 p.m. – 2:55 p.m. | Carrying over individualization of care into the embryology laboratory David F. Albertini, PhD |
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| 3:00 p.m. – 3:30 p.m. | Coffee Break, Poster Viewing & Visit the Exhibition | |
| 3:30 p.m. – 5:30 p.m. | Session 8 – Plenary: Hidden treasures discovered Chairs: Andrea Weghofer, MD, PhD, MS, MBA and David H. Barad, MD, MS |
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| 3:30 p.m. – 4:00 p.m. | Modelling human embryology in a dish Mijo Simunovic, PhD |
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| 4:00 p.m. – 4:30 p.m. | Can tacrolimus treatment affect pregnancy outcomes in presence of maternal immune abnormalities? Frederick W. K. Kan, PhD |
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| 4:30 p.m. – 5:00 p.m. | An immune clock that controls pregnancy Brice Gaudilliere, MD, PhD |
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| 5:00 p.m. – 5:30 p.m. | A new frontier in the IVF laboratory: Automatic vitrification of oocytes and embryos Pasquale Patrizio, MD, MS |
Day 3, Sunday, November 18, 2018
| Good morning – Welcome Coffee, served prior to the start of the day | ||
| 9:00 a.m. – 10:30 a.m. | Session 9 – Plenary: Hot topics Chairs: Zeev Shoham, MD and John Zhang, MD, MSc, PhD |
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| 9:00 a.m. – 9:30 a.m. | Oogonial stem cells after all? Evelyn E. Telfer, PhD |
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| 9:30 a.m. – 10:00 a.m. | Stem cells and in the treatment of human infertility Sherman J. Silber, MD |
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| 10:00 a.m. – 10:30 a.m. | Nuclear transfer: History and potential application in human reproduction John Zhang, MD, MSc, PhD |
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| 10:30 a.m. – 11:00 a.m. | Coffee Break | |
| 11:00 a.m. – 1:00 p.m. | Closing Session: Most Interesting recent 2018 presentations and yet unpublished data Chairs: David F. Albertini, PhD and Norbert Gleicher, MD |
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| 11:00 a.m. – 11:20 a.m. | The evolving potential translational importance of cumulin (GDF9: BMP15) treatments for female fertility Aritro Sen, PhD |
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| 11:20 a.m. – 11:40 a.m. | Does platelet-rich (autologous) plasma (PRP) “rejuvenate” ovaries and endometrium? Andrea Weghofer, MD, PhD, MS, MBA |
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| 11:40 a.m. – 12:00 p.m. | Human blastocysts of normal and abnormal karyotypes display distinct transcriptome profiles Frederick L. Licciardi, MD |
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| 12:00 p.m. – 12:20 p.m. | Transferring chromosomally “abnormal embryos” after PGS/PGT-A: a worldwide survey of IVF centers by www.IVF-Worldwide.com Pasquale Patrizio, MD, MS |
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| 12:20 p.m. – 1:00 p.m. | The FRMC Closing Lecture Will human embryos fly and more? Ali H. Brivanlou, PhD |
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| 1:00 p.m. | Closing Remarks Norbert Gleicher, MD |