Male Infertility


The first part of this course provides an outline of standard andrologic procedures, and then in the second part provides a detailed explanation of Dr. Sherman Silber's recommended approach to male infertility.


About this course

  • Detailed explanations

    Detailed explanation on treatment options for male infertility, as practiced and recommended by one of the world's experts

  • Interactive content

    Course broken down into modules and chapters, and supplemented with images, graphs, photos, animations and videos

  • Expert input

    Course developed by Dr. Sherman Silber - a pioneer and world's preeminnant authority in microsurgery and infertility

Course curriculum

  • 1
    Standard andrologic procedures - introduction
    • Introduction
    • Data that should be recorded
  • 2
    Laboratory & physical examination
    • Laboratory & physical examination
  • 3
    Investigations
    • Introduction
    • Normal volume & liquid distribution
  • 4
    Normal sperm analysis
    • Biophysical characteristics
    • Semen analysis
    • Normal appearance of sperm
    • The 1987 WHO Manual Normal Spermatozoon Definition
    • Biochemical characteristics of the semen analysis
    • Epididymal markers
    • Prostate markers
    • Semen analysis
    • Seminal vesicle markers
    • Definition of semen pathology
    • Semen analysis
    • Indications
    • Tests available
  • 5
    Causes of male infertility
    • Chromosomal
    • Testicular
    • Hormonal
    • Other organs
    • General health & lifestyle
  • 6
    Initial tests for immediate differential diagnosis
    • Hormonal profile for the following impairments
    • Urine analysis
    • Ultrasound of testis
    • Chromosomal analysis for the following impairments
    • Testicular biopsy
    • Drugs linked to male infertility by decreasing spermatogenesis
    • Non-obstructive Azoospermia or Severe Oligospermia
    • Testicular biopsy
  • 7
    Treatment of male infertility - introduction
    • Introduction
    • References
  • 8
    How to interpret the semen analysis
    • How to interpret the semen analysis
    • Sperm morphology
    • Other various tests of sperm function
    • Tables & figures
    • References
  • 9
    Treatment of male infertility
    • Critique of Classic Andrologic Treatments
    • Tables & figures
    • References
  • 10
    Azoospermia
    • Evaluation of the Azoospermic man
    • Microsurgical Vasoepididymostomy
    • MESA: Microsurgical Sperm Aspiration with ICSI
    • Testicular sperm extraction (RESE) for Non-obstructive Azoospermia (NOA)
    • Best method for micro-TESE
    • Tables & figures
    • References
  • 11
    Karyotyping of infertile males & their ICSI offspring
    • Karyotyping
    • Klinefelter’s Syndrome
    • Tables & figures
    • References
  • 12
    Single sperm cryopreservation
    • Single sperm cryopreservation
    • References
  • 13
    The genetic control of male infertility & understanding the Y chromosome
    • The genetic control of male infertility & understanding the Y chromosome
    • The Y chromosome & ICSI
    • AZFa
    • AZFb
    • AZFc
    • The DAZ gene family
    • Evolution of the human Y chromosome
    • Other male infertility genes not discernible on the Y chromosome
    • Transmission of Y deletions to ICSI offspring
    • Tables & figures
    • References
  • 14
    Spermatogenic stem cell cryopreservation & transplantation
    • Spermatogenic stem cell cryopreservation & transplantation
    • Tables & figures
    • References
  • 15
    Making sperm from skin cells
    • Making sperm from skin cells
    • Tables & figures
  • 16
    Identification of spermatogonial stem cells & genetic control of all stages of spermatogenesis
    • Identification of spermatogonial stem cells & genetic control of all stages of spermatogenesis
    • References

Instructor

Dr. Sherman Silber

Dr. Sherman Silber, a pioneer in microsurgery and infertility, is considered a leading authority on IVF, sperm retrieval, ICSI, vasectomy reversal, tubal ligation reversal, egg and embryo freezing, testicle and ovary freezing and transplantation, and the reproductive biological clock. He performed the world’s first microsurgical vasectomy reversal, as well as the first testicle transplant, in the 70’s, and now in the current century, the world’s first ovary transplant. He was the first to develop the TESE and MESA techniques for retrieving testicular and epididymal sperm in azoospermic men. He headed the clinical MIT team that first mapped and sequenced the Y chromosome in infertile men and helped to discover the now famous DAZ gene for male fertility. His research includes also the study of reproduction and fertility in zoo animals and endangered species. Most recently he has perfected the preservation of fertility for cancer patients with ovarian freezing and transplantation and thereby figured out how to extend the reproductive biological clock of women. He has helped pioneer minimal ovarian stimulation to reduce IVF costs.  He is a urologist who teaches very difficult gynecologic procedures (like tubal reversal and adenomyectomy) to gynecologists. He has even recently answered the age-old question of why the dinosaurs went extinct by extending his research on male infertility and the Y chromosome, discovering that the change in earth temperature 65,000,000 years ago led to the birth of a skewed male/female sex ratio.

He is the author of three medical textbooks, five best-selling books for the layman and more than 200 scientific papers on human infertility and reproduction. His most recent book, “How to Get Pregnant”, published by Little, Brown and Company in 2007, is a completely revised and updated edition of his classic series of “How To Get Pregnant” books, which have been major bestsellers in the United States. Dr. Silber’s books have been published in English, Spanish, German, and Russian.

Dr. Silber went to medical school at the University of Michigan, did post-graduate training at Stanford University, and then again at the University of Michigan. From 1967 to 1969, he provided medical care via the US Public Health Service to Eskimos, Indians, and Aleuts. Then he taught at the University of Melbourne Medical School in Australia, and later at the University of California Medical School in San Francisco. He is a scientific collaborator at MIT in Cambridge, Massachusetts, a full professor at the University of Amsterdam, and at the Kato Clinic in Tokyo. His major clinical medical practice is at St. Luke’s Hospital in St. Louis, Missouri.  He always gives credit for his surgical dexterity to the training he received during medical school from an uneducated but brilliant janitor, Jimmy Crudup, who washed instruments in the animal lab at the University of Michigan.