Endometrial scratching: Multiple protocols show promise

Dear IVF-Worldwide Members,

We bring you an important new publication that challenges long-held assumptions and provides critical clarification in reproductive medicine. A comprehensive new systematic review published this week in Reproductive BioMedicine Online reveals that endometrial scratching with multiple-biopsy protocols may benefit carefully selected patients.

Meta-analysis: by the numbers
This is not another small study. This is the most comprehensive individual participant data (IPD) meta-analysis to date:

• 4,112 patients

• 13 trustworthy randomized controlled trials based on individual participant data

• 20+ years of research

Overall results:
Modest but statistically significant improvement in live birth rates (OR 1.29, 95% CI 1.02-1.64) 

Why it matters: biological heterogeneity
The authors reveal a critical insight that explains decades of conflicting research.

Clinical recommendations
Rather than abandoning the practice, the authors advocate at least for a targeted approach.

The clinical bottom line
The evidence suggests endometrial scratching deserves reconsideration.

What this means for your practice
Discuss endometrial scratching with your patients undergoing IVF.

Read the full publication
Access the complete systematic review now in Reproductive BioMedicine Online.

Discuss with IVF-worldwide community
This is a landmark paper that deserves discussion. Join your IVF-Worldwide colleagues in sharing your clinical experience with endometrial scratching.

The IVF-Worldwide Editorial Team
Advancing evidence-based reproductive medicine globally.

contact@ivf-worldwide.com

On behalf of the ivf-worldwide.com team.

Zeev Shoham and Milton Leong