More Medication Isn't Always Better: Rethinking Gonadotropin Dosing for Poor Responders: For years, fertility specialists have relied on a simple equation: struggling ovaries need higher hormone doses. But does this conventional wisdom actually work? A prospective, randomized controlled trial across six Hungarian fertility centers investigated whether elevated gonadotropin protocols truly benefit poor responder patients. Researchers compared standard versus high-dose stimulation strategies in nearly 200 women with low ovarian reserve, measuring clinical pregnancy, live birth, and cumulative success rates. The results challenge long-held assumptions about optimal dosing strategies. Discover what the data reveals about balancing treatment intensity with real-world outcomes, and what it means for your patients and practice.